This study was aimed to statistically optimize coating of oxynutynin chloride tablet for pH dependant colon targeting delivery system. The core tablets were evaluated for pharmacopoeial and non pharmacopoeial test. Enzyme α-galactosidase concentration was defined by lactose degradation study. In presence of eudragit RL 100 release rate was significantly increased which proved hydrophilic characteristic of polymer improved water absorption and ultimately drug release. A 32 full factorial design was used for preparation of coating of tablet. The experimental design of coating of tablets comprised of two independent variables: amount of eudragit E 100 and acryl EZE, each at three different levels and the dependent variable were time required to release 50% and 85% of drug. The in-vitro drug release study of F1-F9 was carried out by change over media method (0.1 N HCl buffer, pH 1.2, phosphate buffer, pH 6.8 and enzymatic phosphate buffer, pH 6.8 with enzyme 2%) and F5 batch was optimized. Drug release mechanism was studied. Conclusively, pH dependant colon targeted oxynutynin chloride tablets were successfully optimized.
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